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Sains Malaysiana 52(7)(2023): 2069-2093
http://doi.org/10.17576/jsm-2023-5207-14
Advances in the
Bioregulation of Mesenchymal Stem Cells by Low-Level Laser Therapy during Bone
Formation: A Narrative Review
(Kemajuan dalam Kawal Atur Sel Stem Mesenkima oleh Terapi Laser Tahap Rendah semasa Pembentukan Tulang: Kajian Naratif)
WANG YAN PEI1,
MOHAMAD ARIF AWANG NAWI1 & NORMA AB RAHMAN2,*
1School of Dental Sciences, Universiti Sains Malaysia, Health Campus,16150 Kubang Kerian, Kelantan, Malaysia
2Orthodontic Unit, School of Dental Sciences, Universiti Sains Malaysia, Health
Campus, 16150 Kubang Kerian,
Kelantan, Malaysia
Diserahkan: 11 November 2022/Diterima: 5 Julai 2023
Abstract
This article reviews the progress of research on the modulation of the
biological effects of low-level laser therapy (LLLT) on Mesenchymal stem cells
(MSC) and the influence of the basic LLLT parameters and irradiation scenarios. A thorough search of the literature
in the PubMed, Web of Science and Embase databases, including articles published in peer-reviewed journals, was
conducted to collect relevant information on LLLT and MSCs. A comprehensive
search of PubMed, Web of Science, and Embase databases was performed using the keywords "Low level laser,"
"mesenchymal stem cells," " cell proliferation," and
"osteogenic differentiation." The search was limited to studies
published in English between 2009 and 2022, including in vitro and in vivo
studies. LLLT has the potential to promote MSC proliferation
and osteogenic differentiation, with significant applications in bone tissue
engineering. Factors that influence the biological effects of LLLT on MSC
include cell type, culture medium, duration of irradiation, the frequency of
laser irradiation, irradiation spot size, and type of light flux distribution. The limitations of
this review include heterogeneous experimental conditions and the inability to
design experiments that consider all influencing factors simultaneously.
Keywords: Cell proliferation; low level laser; mesenchymal
stem cells; osteogenic differentiation
Abstrak
Artikel ini mengkaji kemajuan penyelidikan mengenai modulasi kesan biologi terapi laser peringkat rendah (LLLT) pada sel stem mesenkima (MSC) dan pengaruh parameter LLLT asas dan senario penyinaran. Pencarian teliti kepustakaan dalam pangkalan data PubMed, Web of Science dan Embase, termasuk artikel yang diterbitkan dalam jurnal semakan rakan sebaya, telah dijalankan untuk mengumpul maklumat yang berkaitan tentang LLLT dan MSC. Carian komprehensif pangkalan data
PubMed, Web of Science dan Embase telah dilakukan menggunakan kata kunci ‘laser tahap rendah’, ‘sel stem mesenkima’, ‘percambahan sel’ dan ‘pembezaan osteogenik’. Pencarian terhad kepada kajian yang diterbitkan dalam bahasa Inggeris antara 2009 dan 2022, termasuk kajian in vitro dan in vivo. LLLT berpotensi untuk menggalakkan percambahan MSC dan pembezaan osteogenik dengan aplikasi penting dalam kejuruteraan tisu tulang. Faktor yang mempengaruhi kesan biologi LLLT pada MSC termasuk jenis sel, medium kultur, tempoh penyinaran, kekerapan penyinaran laser, saiz tempat penyinaran dan jenis taburan fluks cahaya. Kekangan dalam ulasan ini termasuk keadaan uji kaji heterogen dan ketidakupayaan untuk mereka bentuk uji kaji yang mempertimbangkan semua faktor yang mempengaruhi secara serentak.
Kata kunci: Laser tahap rendah; pembezaan osteogenik; percambahan sel; sel stem mesenkima
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*Pengarang untuk surat-menyurat; email: drnorma@usm.my
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